Length Variation in HV2 of the Human Mitochondrial DNA Control Region
- 1 July 2001
- journal article
- other
- Published by ASTM International in Journal of Forensic Sciences
- Vol. 46 (4) , 862-870
- https://doi.org/10.1520/jfs15059j
Abstract
Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion.Keywords
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