Intravesical Electrical Stimulation—An Experimental Analysis of The Mechanism of Action
- 1 September 1992
- journal article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 148 (3 Part 1) , 920-924
- https://doi.org/10.1016/s0022-5347(17)36778-2
Abstract
The working mechanism of intravesical electrical stimulation (IVES) was evaluated in alpha-chloralose anaesthetized cats and rats. IVES involved a direct activation of bladder mechanoreceptor afferents of the A delta type and as a consequence a central reflex activation of the detrusor. The detrusor response was abolished by bilateral transection of the S1-S3 dorsal roots and by intravesical instillation of lidocaine. The optimal stimulation frequency was 20 Hz. The results offer a theoretical rationale for the use of IVES as treatment of weak detrusor contractility in man.Keywords
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