Bidirectional isotachophoresis on a planar chip with integrated conductivity detection
- 9 October 2002
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 127 (11) , 1413-1419
- https://doi.org/10.1039/b207462a
Abstract
The use of a miniaturised planar separation device with integrated conductivity detection for performing bidirectional isotachophoresis (ITP) is described. The chips were produced in poly(methyl methacrylate) (PMMA) using a milling procedure. To enable bidirectional ITP the devices were designed to inject samples into the centre of the separation channel and incorporated two integrated on-column conductivity detectors, positioned at opposite ends of this channel. When used with a hydrodynamic sample transport system the devices were used for the analysis of a range of small ions: NH4 +; Na+; Mg2+; Ca2+; Li+; NO3 −; ClO4 −; SO4 2−; F−. Results sucessfully achieved included the simultaneous separation of three anions and three cations.Keywords
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