Experimental Measurement of the Strength of a Cα−H···O Bond in a Lipid Bilayer
- 9 April 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (17) , 5362-5363
- https://doi.org/10.1021/ja049826h
Abstract
Due to the apolar nature of the lipid bilayer, the weak Cα−H···O H-bond is thought to contribute significantly toward the stability of transmembrane helical bundles such as glycophorin A (GPA). Here for the first time we measured the strength of such a bond, using vibrational frequency shifts of a dimeric and nondimeric variants of GPA containing a Gly CD2 label. Although the resulting estimated bond strength of 0.88 kcal/mol is relatively weak, several such bonds could contribute significantly toward bundle stabilization.Keywords
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