BACLOFEN VERSUS DIAZEPAM FOR THE TREATMENT OF SPASTICITY AND LONG-TERM FOLLOW-UP OF BACLOFEN THERAPY

  • 1 January 1985
    • journal article
    • research article
    • Vol. 4  (5) , 278-284
Abstract
Baclofen (25 to 60 mg per day) and diazepam (10 to 40 mg per day) were evaluated for spasticity reduction in a double-blind, crossover study in 13 patients over a period of 19 weeks. Both drugs produced overall improvement and there was no significant difference in preference for one or other treatment. Side-effects, especially excessive daytime sedation, were more common in the diazepam group. In a companion baclofen long-term study, 18 spastic patients were treated with baclofen for an average of 4 years. Baclofen discontinuation in this group resulted in a worsening of spastic signs and symptoms in 16 patients, with no evidence of drug tolerance even after many years of baclofen therapy.

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