Congenital Malformations of the Central Nervous System: III.--Risk of Malformation in Sibs of Malformed Individuals

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Abstract
The observed incidence of malformations of the central nervous system in sibs born after a first propositus was 2.77%. This is approx. 6 times the expected incidence of 0.45%. In estimating the expected incidence, we have taken account of the secular trend of the malformation rate in Birmingham in the years 1940-47, as well as of variations in the rate associated with maternal age and parity.