Lack of Effect of Prostaglandin Inhibition on Calcium Excretion in Normal Volunteers

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Abstract
Administration of indomethacin to patients with hypercalciuric nephrolithiasis decreased urinary Ca excretion, implying a possible pathogenic role for renal prostaglandins in hypercalciuria. Indomethacin, ketoprofen and aspirin were administered to normal volunteers for 6 days and assessed daily creatinine clearance and urinary excretion of Na and Ca. In contrast to previous studies, subjects were maintained on a constant metabolic diet. These nonsteroidal anti-inflammatory drugs decreased urinary Na excretion but had no effect on creatinine clearance or urinary Ca excretion. An important physiologic role of renal prostaglandins in renal calcium excretion in normal subjects is not supported.