Recovery of morphine from a controlled-release preparation: A source of opioid abuse
- 15 December 1990
- Vol. 66 (12) , 2642-2644
- https://doi.org/10.1002/1097-0142(19901215)66:12<2642::aid-cncr2820661229>3.0.co;2-b
Abstract
MS‐Contin (Purdue‐Fredrick, Norwalk, CT) is a controlled‐release preparation of morphine sulfate that has demonstrated efficacy in the management of chronic cancer pain problems. It has recently come to the attention of the authors that MS‐Contin represents a potential source of opioid abuse through the extraction and intravenous injection of the morphine from this preparation. the authors describe a simple aqueous extraction method that was used to quantitatively determine the extent to which morphine could be obtained from MS‐Contin tablets.This publication has 4 references indexed in Scilit:
- Steady-State Pharmacokinetics of Controlled Release Oral Morphine Sulphate in Healthy SubjectsClinical Pharmacokinetics, 1986
- High-Dose Morphine and Methadone in Cancer PatientsClinical Pharmacokinetics, 1986
- Steady-state kinetics and analgesic effect of oral morphine in cancer patientsEuropean Journal of Clinical Pharmacology, 1983