Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene
- 1 April 1997
- journal article
- Published by Springer Nature in Nature
- Vol. 386 (6627) , 796-804
- https://doi.org/10.1038/386796a0
Abstract
The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.Keywords
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