Mianserin: Determination of Therapeutic Dose Range
- 1 July 1980
- journal article
- research article
- Published by S. Karger AG in International Pharmacopsychiatry
- Vol. 15 (2) , 111-117
- https://doi.org/10.1159/000468421
Abstract
Mianserin hydrochloride is a tetracyclic antidepressant with an EEG and clinical activity profile similar to amitriptyline. To investigate the drug's optimal dosage range, a 6-week open comparative trial sequentially assigned 12 depressed patients to one of three dose ranges (60, 90 and 120 mg). Improvement occurred in depressive symptomatology in all three treatment groups. There was no differential improvement noted in any group; however, the incidence of adverse effects was greater in the middle (90 mg) and high (120 mg) dose ranges.Keywords
This publication has 1 reference indexed in Scilit:
- The effect of a tetracyclic antidepressant compound, Org GB94, on the turnover of biogenic amines in rat brainBiochemical Pharmacology, 1976