Rutin and Other Flavonoids as Potentiators of Terminal Vascular Responses to Epinephrine and as Antagonists of Vasodepressor Materials

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Abstract
The terminal vascular bed of the rat mesoappendix was used to determine the effect of rutin and other flavonoids on the response of the smooth muscle components to topically applied epinephrine. Alteration in the threshold concn. of epinephrine necessary to produce constriction of metarterioles and precapillary sphincters was used as a measure of activity. Intravenously injd. rutin (in propylene glycol) in doses of 2.5-50 mg./kg. reduced the epinephrine threshold to about 40% of the initial level. A dose of 1 mg./kg. was somewhat less effective and 0.5 mg./kg. was without effect. Rutin given by stomach tube was effective in reducing the epinephrine threshold within 75 min. and remained effective for at least 5.5 hrs. Sodium rutin acid succinate, methylated hesperidin chalcone, and the Na salt of hesperidin chalcone also reduced the threshold to topically applied epinephrine. Rutin antagonized the vasodepressor effect of edema fluid from frostbitten limbs as well as the effect of hepatic vasodepressor material (ferritin).