The barrier function of the outer membrane of Pseudomonas maltophilia in the diffusion of saccharides and β-lactam antibiotics
- 1 July 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 60 (1) , 85-88
- https://doi.org/10.1016/0378-1097(89)90082-7
Abstract
This paper reports that the efficiency of solute diffusion through the outer membrane of Pseudomonas maltophilia is roughly 3 to 5% of that of Escherichia coli. This is despite the fact that the outer membrane pore(s) is only a little smaller than that of E. coli. These results suggest that P. maltophilia has a low copy number of porin(s). The outer membrane of antibiotic resistant clinical isolates showed even less efficient permeability towards saccharides and antibiotics than the laboratory strains.Keywords
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