Phosphonate Isosteres of 2′,3′-Didehydro-2,3-dideoxynucleoside Monophosphates: Synthesis and Anti-HIV Activity
- 1 January 1991
- journal article
- oral communications
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (1-3) , 371-375
- https://doi.org/10.1080/07328319108046482
Abstract
Phosphonate analogues of d4T and d4A monophosphates have been synthesized using stereocontrolled addition of dimethyl hydroxymethylphosphonate to furanoid glycals. The new phosphonates exhibited a potent activity against HIV.Keywords
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