Further Studies on Brucella-phage

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Abstract
Among the old cultures of Brucella brucei strains Brucella phages appeared very often. In examinations including 26 of our own phages, 2 Russian phages, standard Brucella strains (WHO), and our own Brucella collection, we did not find any of the phages to be specific only for one Brucella type. "Tbilisi" phage and a few of our own phages selectively attack bovis strains; however, a certain group of bovis strains was non-susceptible to these phages. They did not lyse the majority of the melitensis and suis strains, which, however, remained susceptible to their own phages. The remaining phages are polyvalent, in that they are not able to differentiate between Brucella types. The atypical Brucella strains showed the most pronounced heterogeneity. "R" strains are in principle resistant to phage. It is not possible to determine certain phagic groups analogous to Salmonella, Shigella, Staphylococcus and others. "Tbilisi" phage and certain of our phages may be used for the differentiation of Brucella types in addition to the classic method, although with reservations. It is possible that the "Tbilisi" phage as our phages can[long dash] by way of adaptation[long dash]be led to a 100% specific lysis of the bovis strains. These studies are in progress.

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