PORCINE PROLIFERATIVE ENTERITIS - EXPERIMENTALLY INDUCED DISEASE IN CESAREAN-DERIVED COLOSTRUM-DEPRIVED PIGS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 43  (9) , 1622-1630
Abstract
The hypotheses that porcine proliferative enteritis is an infectious disease and that Campylobacter sputorum ssp. mucosalis (CSM) is involved in the development of this disease were experimentally tested. Three experiments were conducted with 10 wk old, cesarean-derived colostrum-deprived pigs. Of 22 pigs given homogenized mucosal scrapings (crude inocula) intragastrically, 15 had gross and/or microscopic lesions of proliferative enteritis. Of 10 pigs inoculated with cultures of both CSM and Salmonella cholerae-suis, 2 had evidence of proliferative enteritis. The 4 pigs treated with S. cholerae-suis only had diffuse fibrinous gastroenteritis without evidence of mucosal proliferation. Proliferation enteritis was produced in 1 of 5 pigs inoculated with pure cultures of CSM. Proliferative lesions in the intestine were characterized by the proliferation of immature crypt epithelial cells. Affected cells contained variable numbers of curved, intracytoplasmic Campylobacter sp. organisms. The CSM organism was isolated from the intestinal mucosa of 8 pigs treated with either crude inocula or cultures of CSM.

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