Cytologic Smears from the Mouth: Cellular Changes in Disease and after Radiation

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Abstract
Smears were prepared from the mouths of 893 patients. On the basis of histologic studies or the observation of clinically evident disease, 263 were known to have cancer. Of the smears from the 263 patients with cancer, the results of 73% were positive, 23% were "suspicious", and 4% were falsely negative. Cytologic smears from the mouth may be used in the study of changes induced in cells as the result of radiation. By means of comparative smears, one may study the changes in cells (1) from a cancer, (2) from tissue surrounding the neoplasm, and (3) from the corresponding tissue of the opposite, healthy side of the mouth.

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