The vascular E-selectin binds to the leukocyte integrins CD11/CD18
- 1 April 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in Glycobiology
- Vol. 3 (2) , 131-136
- https://doi.org/10.1093/glycob/3.2.131
Abstract
Leukocyte adhesion involves at least three molecular families of adhesion proteins: the leukocyte integrins CD11/CD18, the intercellular adhesion molecules (ICAMs) and the carbohydrate-binding L-, E- and P-selectins. The intercellular adhesion molecules are well-known ligands for the CD11/CD18 integrins. We now show that E-selectin specifically binds to the sialyl Lex carbohydrate epitopes of leukocyte integrins. Thus, the different families of leukocyte adhesion molecules form an integrated adhesion network.Keywords
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