Immunofluorescent Skin Test in Systemic Lupus Erythematosus

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Abstract
The results of immunofluorescent stains of skin biopsy specimens from 29 patients with systemic lupus erythematosus (SLE) were correlated with the presence, type, and severity of renal disease. Seventy percent of 23 patients with renal disease had immunofluorescent-positive findings of skin biopsies while 67% of six patients without renal disease had positive findings of skin biopsies. Three of five patients with renal biopsy-proven diffuse proliferative glomerulonephritis had positive findings of skin biopsies (60%), as did two of three patients with focal, proliferative glomerulonephritis and the single patient with membranous glomerulonephritis. There was no correlation between the presence of immune deposits on skin and the severity of the renal disease. There appears to be no correlation between the presence of the immunofluorescent skin test and the type or severity of renal disease in SLE.