Cutaneous Cytodestructive Potency of Lignans

Publisher Website
Google Scholar
Abstract
Four lignans: podophyllotoxin (A), 4′-demethyl-podophyllotoxin (B), α-peltatin (C), and β-peltatin (D) are the podophyllin ingredients producing lesional necrosis after application on condylomata acuminata. This study evaluates comparatively their destructive potency on rabbit skin after 10-day repeated applications. Any visible changes or increase on skinfold thickness induced by each of the drugs tested as 0.01 0.05, 0.1 and 0.5% ethanolic preparations were followed. These variables demonstrated a close covariation; the analyses revealed a significant difference with respect to influence on measurements according to the following ranking order: A > C > D = B.

This publication has 0 references indexed in Scilit: