Evaluation of Drugs in Ointment for Mydriasis and Cycloplegia

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Abstract
• Ointment preparations of cyclopentolate hydrochloride and tropicamide were compared with aqueous drops of these medications for the production of mydriasis and/or cycloplegia in clinic patients. Mydriasis and/or cycloplegia could be accomplished by the single application of a minute volume (around 0.005 ml) of ointment containing these drugs. With the use of ointment preparation, ocular irritation was minimal, and there was no interference with subsequent ocular examination. A delivery system was devised with a piece of silicone-rubber tubing that was filled with an ointment preparation. By squeezing the tubing, a minute volume (about 0.005 ml) of ointment preparation was expressed.

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