Lack of serological evidence for an association between simian virus 40 and lymphoma
- 23 January 2003
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 104 (4) , 522-524
- https://doi.org/10.1002/ijc.10993
Abstract
Recent studies have implicated simian virus 40 (SV40) in non‐Hodgkin's lymphomas based on detection of SV40 DNA sequences. We employed a virus‐like‐particle (VLP)‐based enzyme immunoassay for antibodies to SV40 to test sera from 520 lymphoma cases and 587 controls in Spain. The SV40 seroprevalence was 9.5% in controls and 5.9% in cases. Antibody levels of the positive sera were low. There was no association of SV40 seropositivity with any subtype of lymphoma. VLPs of the human BK virus substantially inhibited the SV40 reactivity of human sera. There was no serological evidence of widespread SV40 infection and no association of SV40 seropositivity with human lymphomas in Spain.Keywords
This publication has 4 references indexed in Scilit:
- Simian virus 40 infectionin lymphoproliferative disordersThe Lancet, 2003
- Association between simian virus 40 and non-Hodgkin lymphomaThe Lancet, 2002
- Presence of simian virus 40 DNA sequences in human lymphomasThe Lancet, 2002
- Does SV40 infection contribute to the development of human cancers?Reviews in Medical Virology, 2000