A singular substituent effect in the nickel(0) mediated cocyclisation of octa-1,7-diynes with alkynols. One-step synthesis of tetralin lactones from acyclic precursors
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 5,p. 277-278
- https://doi.org/10.1039/c39910000277
Abstract
Whereas the reaction of simple octa-1,7-diynes is fruitless, those bearing ester groups on the terminal positions react with alkynols in the presence of stoichiometric amounts of a nickel(0) reagent derived from NiCl2(PPh3)2 and BunLi to give tetralin lactones in moderate to good yields.Keywords
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