CYTOPLASMIC HYALINS RESEMBLING MALLORY'S ALCOHOLIC HYALINS IN PULMONARY CARCINOMA CELLS

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Abstract
Two cases with Mallory body (MB)-like cytoplasmic hyalins in cells, which were quite uncommon as MB-having cells, were presented. The cases were 61- and 59-year-old males. MB-like hyalins were found in large cell carcinoma cells of giant cell type of the lung. The cells containing MB-like hyalins frequently showed a hydropic swelling of the cytoplasm with pyknotic, or wrinkled nuclei. Histochemical properties of the hyalins were just similar to those of hepatic MBs in alcoholic liver diseases. Electronmicroscopically, the hyalins were composed of granular, or homogeneous electron dense materials with the peripheral meshwork of randomly oriented fibrils measuring about 100 .ANG. in diameter. These were stained with anticytokeratin antibodies, suggesting the relatedness of the hyalins to intermediate-sized filaments of the cytokeratin type.