Myoglobin protects against endothelial cell membrane damage associated with hydrogen peroxide or xanthine/xanthine oxidase
Open Access
- 15 March 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 319 (1-2) , 145-150
- https://doi.org/10.1016/0014-5793(93)80055-y
Abstract
Oxymyoglobin at ‘physiological’ concentrations of 20–100 micromolar protected cultured endothelial cells from damage by xanthine/xanthine oxidase or by hydrogen peroxide. Metmyoglobin also provided a degree of protection, but apomyoglobin was ineffective. Protection was enhanced in the presence of ascorbate (0.01–1 mM). Myoglobin may have a physiological role in the protection of muscular tissue from isehaemia/reperfusion‐induced damage.Keywords
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