Mechanisms of Glucose-Induced Hyperemia in the Jejunum

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Abstract
The effects of placement of 3 glucose analogs into the jejunal lumen, with or without bile, on local blood flow, O2 consumption, and glucose absorption were studied. Both glucose and 3-O-methyl glucose were absorbed and increased local blood flow when placed into the lumen, 2-deoxy glucose was not absorbed and did not alter local blood flow. Glucose increased but 3-O-methyl glucose did not alter O2 consumption and the former produced a greater hyperemia than the latter. The hyperemic effect of glucose in the jejunal lumen may, at least in part, be related to glucose absorption and an increase in oxidative metabolism. Of the 3 glucoses, only the vascular effect of glucose was influenced by bile. Although the underlying mechanisms of this effect of bile are unknown, the mechanisms apparently require structure specificity.

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