Experimental Studies on Atherogenesis

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Abstract
(1) Not only SHR after the development of hypertension but also SHR in the prehypertensive stage showed acute arterial ring-like fat deposition when fed on the hypercholesterolemic diet. This finding substantiated the view of the importance of disposition in the mechanism of acute arterial fat deposition.(2) The ring-like fat deposition corresponded to the region of the increased permeability, which was indicated by the preponderant distribution of peroxidase reaction products.(3) The localized increase of vascular permeability was likely related to vasoconstriction and dilatation, mainly noted in the latter regions.(4) The degenerated vessel walls with fat deposition were easily dilated with further increase in vascular permeability which accelerated the fat deposition and aggravated the vascular lesions.(5) Such functional phenomena as arterial spasm and dilatation were assumed to cause medial damage following the increased permeability and to accelerate the acute fatty deposition under the existence of hypercholesterolemia and finally to lead irreversible atherogenetic changes.

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