ACCUMULATION AND LOCALIZATION OF GA-67 IN VARIOUS TYPES OF PRIMARY LUNG CARCINOMA

  • 1 January 1978
    • journal article
    • research article
    • Vol. 19  (1) , 28-30
Abstract
The uptake and location of 67Ga were investigated in 15 primary pulmonary carcinomas. The accumulation in the tumor was determined by scintigraphy of the patient, grain counts over fields of tumor cells in autoradiographs of tumor-tissue samples and .gamma. counts in specimens of the tumor. Good correlation was found between the results obtained with these 3 methods. The relationship between accumulation of 67Ga in the tumor and the histologic type of tumor was also studied. Undifferentiated carcinomas, and tumor cells in squamous-cell carcinomas showed significantly more 67Ga than tumor cells in adenocarcinomas. No correlation was found between the presence of inflammatory infiltrates in or around the tumor and the grade of the scintigraphic images. In the autoradiograms, lymphocytes, plasma cells, granulocytes and macrophages showed less radioactivity than the tumor cells-or none at all. Collagen fibers appeared to have bound some 67Ga, but necrotic areas showed no uptake.

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