Effect of renal nerve stimulation on the activity of the tubuloglomerular feedback mechanism

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Abstract
The influence of renal nerve stimulation of the tubuloglomerular feedback mechanism was studied on anesthetized rats. The analysis was made by comparing the single-glomerular filtration rate (SNGFR) measured from late proximal tubules with SNGFR measured from distal tubules in the same nephron. In the former situation the flow to the macula densa cells is interrupted and in the latter the macula densa is influenced by the flow passsing by. In the control situation, the SNGFR measured proximally was 47.7 .+-. 2.2 nl .cntdot. min-1 (mean .+-. SE) and 40.1 .+-. 1.8 measured distally indicating an activated tubuloglomerular feedback. During renal nerve stimulation (2-3 Hz), the SNGFR fell to 38.5 .+-. 2.3 and 33.5 .+-. 1.7 when measured proximally and distally, respectively. The tubuloglomerular feedback mechanism is unaffected by renal nerve stimulation.

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