DIFFERENTIAL NEURO-ONCOGENICITY OF STRAINS OF JC VIRUS, A HUMAN POLYOMA-VIRUS, IN NEWBORN SYRIAN-HAMSTERS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (3) , 718-720
Abstract
The neurooncogenicity of 3 recently isolated strains of the human polyoma virus, JC virus, was determined by intracerebral inoculation of newborn Syrian golden hamsters. All 3 strains produced malignant brain tumors in a majority of inoculated animals during a 6.5 mo. observation. The results obtained with the MAD-2 strain, 19 of 20 animals with cerebellar medulloblastomas and 0 of 20 animals with pineal gland tumors, were quite similar to those observed previously with the prototypic strain of JC virus, MAD-1. Inoculation of the MAD-4 strain, however, resulted in 10 of 22 animals with pineal gland tumors and only 10 of 22 animals with tumors in the cerebellum. The MAD-3 strain was neurooncogenic, but too few animals lived to be weaned to provide significant additional information. The basis for the apparent predilection of the MAD-4 strain for the pineal gland is unknown. Two hamsters in the experiment developed extracranial neuroblastomas.

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