Dipropylacetic Acid* Plasma Levels; Diurnal Fluctuations During Chronic Treatment with Dipropylacetamide
- 1 January 1981
- journal article
- research article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 3 (3) , 297-302
- https://doi.org/10.1097/00007691-198103000-00012
Abstract
Diurnal variation in dipropylacetic acid (DPA) plasma levels was investigated in 47 and 42 epileptic patients, chronically treated with sodium dipropylacetate and dipropylacetamide (DPM), respectively, taken alone or in addition to other antiepileptic drugs. Fluctuation in DPA plasma levels was significantly less in patients receiving dipropylacetamide. The slow absorption and the more prolonged plasma half-life of dipropylacetamide accounted for these findings. Although the importance of diurnal fluctuations in DPA levels has not yet been established, possible clinical implications are discussed.Keywords
This publication has 9 references indexed in Scilit:
- Meal‐Dependent Absorption of Enteric‐Coated Sodium ValproateEpilepsia, 1980
- The Delayed Effect of Sodium Valproate on the Photoconvulsive Response in ManEpilepsia, 1979
- Steady‐state kinetics of valproic acid in epileptic patientsClinical Pharmacology & Therapeutics, 1978
- Influence of food and diet on gastrointestinal drug absorption: A reviewJournal of Pharmacokinetics and Biopharmaceutics, 1977
- Efficacy Testing of Valproic Acid Compared to Ethosuximide in Monkey Model: II. Seizure, EEG, and Diurnal VariationsEpilepsia, 1977
- Diurnal Variation of Valproic Acid Plasma Levels and Day‐Night Reversal in MonkeyEpilepsia, 1977
- Efficacy Testing of Valproic Acid Compared to Ethosuximide in Monkey Model: I. Dosage Regimen Design in the Presence of Diurnal OscillationsEpilepsia, 1977
- Clinical Pharmacological Aspects of Valproate SodiumEpilepsia, 1977
- Concentration of Dipropylacetate in PlasmaEpilepsia, 1975