Synthesis of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its enantiomers
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 1,p. 196-198
- https://doi.org/10.1039/p19890000196
Abstract
Convenient syntheses of (R/S)-3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (pyridoglutethimide) and its enantiomers are described; aromatase inhibitory activity was almost entirely confined to the 3R-enantiomer.This publication has 0 references indexed in Scilit: