Lymphocyte-Mediated Antibody-Dependent Cytolysis: Role in Immune Hemolysis

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Abstract
Peripheral blood lymphocytes obtained from normal volunteers were capable of lysing Rh(D)-positive human erythrocytes in the presence of Ig[immunoglobulin]G anti-Rh(D) antibodies. The percent cytotoxicity produced by peripheral blood lymphocytes was approximately equivalent to that produced by unfractionated peripheral blood mononuclear cells. Neither peripheral blood mononuclear cells nor peripheral blood lymphocytes lysed Rh(D)-negative human erythrocytes in the presence of IgG anti-Rh(D) antibody. [The pertinence of these results for understanding the pathogenesis of autoimmune hemolytic anemia was discussed.].