Hybridization of Polynucleotides Using Self-Assembled Monolayer Containing Pyrenyl Groups
- 1 January 2002
- journal article
- research article
- Published by Taylor & Francis in Molecular Crystals and Liquid Crystals
- Vol. 377 (1) , 57-60
- https://doi.org/10.1080/10587250211625
Abstract
To realize an efficient hybridization of polynucleotides, self-assembled monolayer (SAM) containing pyrene groups was prepared on a gold substrate because pyrene molecules have an affinity for nucleic acid bases through van der Waals interaction. The SAM was prepared from 11-(1-pyrene)-1-undeacathiol and 11-mercapto-1-undecanol mixed solution. The mixed SAM gave an efficient hybridization of polyadenylic acid and polyuridylic acid observed by surface plasmon resonance.Keywords
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