INFLUENCE OF CARBON DIOXIDE ON THE EXCITABILITY OF THE VASOMOTOR CENTER IN HYPOGLYCEMIA

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Abstract
Expts. are reported in which in anesthetized normal dogs with and without buffer nerves, the blood pressure response to various concs. of CO2 was detd. at various blood sugar levels. The blood pressure rise to CO2 increases with falling blood sugar. When high concs. (15%) of CO2 are used, the response to CO2 at a normal blood sugar level consists of a fall in blood pressure; this reaction may be converted into a rise when the blood sugar falls below 40 mg. %. The reaction is completely reversible on inj. of glucose. At a low blood sugar level, vagal pulses frequently appear in response to CO3 indicating that sympathetic and parasympathetic centers are sensitized to CO2 by the hypoglycemic state. The physiological predominance of the sympathetic over the parasympathetic is not only maintained but increased in hypoglycemia. The expts. indicate that the vasomotor and the cardioinhibitory centers show an increased excitability during hypoglycemia.

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