The Identification of 5′-Deoxy-5′-Methylthioguanosine in Human Urine by Gas Chromatography/Mass Spectrometry
- 1 July 1992
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 11 (6) , 1275-1292
- https://doi.org/10.1080/07328319208018342
Abstract
5′-Deoxy-5′-methylthioguanosine (MTG) has been identified in human urine by combined gas chromatography/mass spectrometry. Preliminary identification of MTG in the urine of a lung cancer patient was based upon mass spectral comparisons of the trimethylsilylated (TMS) urinary component to both MTA-(TMS)3 and guanosine-(TMS)5. Structural confirmation was obtained by comparing the mass spectral and chromatographic characteristics of authentic MTG to those of the urinary component.Keywords
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