IMMUNOREGULATORY FUNCTION OF SPECIFIC IGG .1. RESULTS IN NONATOPIC SUBJECTS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 120  (2) , 652-654
Abstract
Nonatopic subjects immunized with short ragweed developed reaginic Ig[immunoglobulin]E and blocking IgG antibodies to the antigen. Administration of 250 .mu.g specific ragweed IgG antibodies 1 wk before, simultaneously or up to 2 wk after the start of immunization with ragweed extract abrogated the production of anti-ragweed reaginic antibodies measured by skin reactivity. Formation of specific ragweed IgG antibodies was unaffected by IgG treatment. There may be a selective regulation of an immune response in humans by IgG.