Organ Removal and Disappearance Half-Time of Synthetic Human Pancreatic Polypeptide
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 25 (3) , 197-200
- https://doi.org/10.1159/000198830
Abstract
Human pancreatic polypeptide (HPP) was infused into 6 anesthetized dogs at a constant dose of 1.0 .mu.g/kg per h over 60 min. Blood samples for RIA [radioimmunonassay] of pancreatic polypeptide were taken repeatedly from a carotid artery, jugular vein, femoral vein, renal vein and mesenteric vein. The calculated tissue removal of HPP in a single passage through these 4 vascular beds ranged from 24-40% and did not differ significantly among them. Mean disappearance half-time on stopping the infusion was 4.5 .+-. 0.8 min. HPP is removed at all of the capillary beds tested.This publication has 5 references indexed in Scilit:
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