A prospective study of the effects of weekly oral methotrexate on liver biopsy.

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Abstract
He results are reported of a prospective study of liver histological findings in twenty‐five patients with severe psoriasis subjected to liver biopsy before and at intervals after the onset of treatment with methotrexate by anintermittent dosage schedule. The pre‐methotrexate liver biopsy findings in forty‐one other severe psoriatics are also summarized. Of the twenty‐five treated patients, four showed a mild inflammatory cell infiltrate and two mild fibrosis before treatment. During treatment only one developed a grade 2 infiltrate and one other grade 2 fibrosis. None has developed cirrhosis. Where minor abnormalities developed, their fluctuating and reversible nature is demonstrated.

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