URIC ACID IN THE CEREBROSPINAL FLUID IN CEREBRAL ATROPHY

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Abstract
CSF uric acid and serum uric acid have been determined in 247 male psychiatric patients. In patients without cerebral atrophy or with a non-progressing atrophy a CSF uric acid concentration of 2.1 microgr/ml with standard deviation of 0.8 was found. In patients with a progressing atro-phy the CSFuric acid concentration was significantly increased. In non-atro-phy and non -progressing atrophy a significant regression of CSF uric acid on serum uric acid was found. In progressing atrophy the regression did not dif-fer significantly from zero. CSF uric acid is partly derived from serum uric acid, and partly from other sources. The main "non-serum" source is probably cerebral nucleic acid catabolism. The Jack of significant regression of CSF uric acid on serum uric acid in progressing cerebral atrophy supports this view.

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