ANTILEUKEMIC EFFECT OF HOMO-AZA-STEROIDAL ESTER OF [PARA-[BIS(2-CHLOROETHYL)AMINO]PHENYL]ACETIC ACID

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 61  (1) , 37-41
Abstract
The homo-aza-steroidal ester of [p-[bis(2-chloroethyl)amino]phenyl]acetic acid, 3.beta.-hydroxy-13.alpha.-amino-13,17-seco-5.alpha.-androstan-17-oic-13,17,-lactam p-bis(2-chloroethyl)aminophenylacetate (ASE), gives a > 50% increased lifespan over controls in the treatment of L1210 mouse leukemia by the i.p., s.c. and oral routes of administration and a > 150% increased lifespan in the treatment of P388 leukemia by the i.p. route (the only route tested). A daily and a day 1, 5 and 9 treatment schedule are equally effective. ASE was compared to the parent compound phenesterin which is inactive in both of these tumor lines. ASE is the 1st steroidal alkylating agent to show activity in L1210 leukemia.

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