The Role of the Adrenergic Nervous System in the Renal Response To Acute Extracellular Fluid Volume Expansion.

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Abstract
The effect of catechol-amine depletion on the natriuresis associated with acute extracellular fluid volume expansion in anesthetized dogs was studied. Paired studies were carried out before and after the administration of parenteral reserpine (0.3 to 0.5 mg/kg total dose). The changes in renal hemo-dynamics during volume expansion were comparable before and after catecholamine depletion, but renal perfusion pressure was signifi -cantly lower after reserpine administration. A modest decrement in natriuresis was seen after reserpine, correlating well with the decrease in perfusion pressure, yet a marked natriuresis still occurred. Impairment of sympathetic efferent nerves via induced catecholamine depletion alters the natriuresis of acute extracellular fluid volume expansion primarily by an effect on renal resistance, and that other as yet unidentified factors are still operative (despite catecholamine depletion) in promoting the natriuresis. Within this context, sympathetic efferent nerves apparently play only a modifying role on the natriuresis of acute extracellular fluid volume expansion.

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