Identification of T cell subsets and B lymphocytes in mouse brain experimental allergic encephalitis lesions.
Open Access
- 1 October 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 129 (4) , 1649-1651
- https://doi.org/10.4049/jimmunol.129.4.1649
Abstract
Tissue section immunoperoxidase staining, employing monoclonal antibodies specific for T cell antigens (Lyt-1, Lyt-2) and B cells (B220), was used to study the brains of mice with experimental allergic encephalitis. Cells bearing phenotypes characteristic of both helper (Lyt-1+2-) and cytotoxic/suppressor (or precursor) (Lyt-2+) T cells, as well as B cells, are present in the perivascular cuffs in brains of EAE mice during active disease and the recovery phase. Lyt-1+ cells comprise 49% of the inflammatory cell population, and Lyt-2+ and B220+ cells are found at frequencies of 10% and 12%, respectively.This publication has 9 references indexed in Scilit:
- Mouse lymph node germinal centers contain a selected subset of T cells--the helper phenotype.The Journal of Immunology, 1982
- Spontaneous remission and acquired resistance to autoimmune encephalomyelitis (EAE) are associated with suppression of T cell reactivity: suppressed EAE effector T cells recovered as T cell lines.The Journal of Immunology, 1982
- In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.Proceedings of the National Academy of Sciences, 1981
- Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.Proceedings of the National Academy of Sciences, 1981
- Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes.The Journal of Immunology, 1981
- A monoclonal antibody that recognizes B cells and B cell precursors in mice.The Journal of Experimental Medicine, 1981
- T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.The Journal of Experimental Medicine, 1980
- NEUROPATHOLOGY OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN INBRED STRAINS OF MICE1980
- Cellular events in the induction of experimental allergic encephalomyelitis in rats.The Journal of Experimental Medicine, 1976