Importance of Heat-Labile Enterotoxin in Colonization of the Adult Mouse Small Intestine by Human EnterotoxigenicEscherichia coliStrains
Open Access
- 1 February 2006
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 74 (2) , 869-875
- https://doi.org/10.1128/iai.74.2.869-875.2006
Abstract
EnterotoxigenicEscherichia coli(ETEC) infections are a significant cause of diarrheal disease and infant mortality in developing countries. Studies of ETEC pathogenesis relevant to vaccine development have been greatly hampered by the lack of a suitable small-animal model of infection with human ETEC strains. Here, we demonstrate that adult immunocompetent outbred mice can be effectively colonized with the prototypical human ETEC H10407 strain (colonization factor antigen I; heat-labile and heat-stable enterotoxin positive) and that production of heat-labile holotoxin provides a significant advantage in colonization of the small intestine in this model.Keywords
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