Polymer Tumorigenesis: Multiple Preneoplastic Clones in Priority Order with Clonal Inhibition

Abstract
Tumorigenesis was induced in CBA-mice by implanting plastic films. Each animal produced multiple karyologically distinct preneoplastic cell clones. These were separated by transferring preneoplastic cells or tissue in various ways to CBA-T6-recipients. It was concluded that one of the clones has neoplastic priority apparently by specifically inhibiting preneoplastic processes in secondary clones.

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