Novel Caprolactones from a Marine Streptomycete
- 17 February 2004
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 67 (3) , 395-401
- https://doi.org/10.1021/np030321z
Abstract
Two new caprolactones, (R)-10-methyl-6-undecanolide (1) and (6R,10S)-10-methyl-6-dodecanolide (2), were identified in the lipid extract of a marine streptomycete (isolate B6007). Their structures were proposed on the basis of GC−MS experiments and proved by synthesis. The absolute configuration of the compounds was established by comparison of the natural and synthetic stereoisomers using chiral gas chromatography. These caprolactones show a moderate phytotoxicity and a promising activity against cancer cells with concomitant low general cytotoxicity.Keywords
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