Identical Vβ T-cell receptor genes used in alloreactive cytotoxic and antigen plus I–A specific helper T cells
- 1 May 1985
- journal article
- letter
- Published by Springer Nature in Nature
- Vol. 315 (6018) , 425-427
- https://doi.org/10.1038/315425a0
Abstract
T lymphocytes involved in the cellular immune response carry cell-surface receptors, responsible for antigen and self recognition. This T-cell receptor molecule is a heterodimeric protein consisting of disulphide-linked α- and β-chains with variable (V) and constant (C) regions1–5. Several complementary DNA and genomic DNA clones have been isolated and characterized6–12. These analyses showed that the genomic arrangement and rearrangement of T-cell receptor genes using VT, diversity (DT), joining (JT) and CT gene segments is very similar to the structure of the known immunoglobulin genes (see ref. 13 for review). We have isolated two cDNA clones from an allospecific cytotoxic T cell, one of which shows a productive Vβ–Jβ–Cβ 1 rearrangement without an intervening Dβ segment. This Vβ gene segment is identical to the Vβ gene expressed in a helper T-cell clone specific for chicken red blood cells and H–2Ib (ref. 14). The other clone carries the Cβ2 gene of the T-cell receptor, but the Cβ2 sequence is preceded by a DNA sequence that does not show any similarity to Vβ or Jβ sequences.Keywords
This publication has 20 references indexed in Scilit:
- Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptideCell, 1984
- The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V geneCell, 1984
- Somatic recombination in a murine T-cell receptor geneNature, 1984
- Isolation of cDNA clones encoding T cell-specific membrane-associated proteinsNature, 1984
- A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chainsNature, 1984
- The mouse T cell receptor: Structural heterogeneity of molecules of normal T cells defined by XenoantiserumCell, 1983
- The mouse T cell receptor: Comparison of MHC-restricted receptors on two T cell hybridomasCell, 1983
- The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumorsCell, 1983
- The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.The Journal of Experimental Medicine, 1983
- Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.The Journal of Experimental Medicine, 1983