SKIN ALLOGRAFT STUDIES IN THE POUCH YOUNG OF THE OPOSSUM

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Abstract
SUMMARY Although adult opossums were shown to exhibit first and secondset rejection phenomena to skin allografts, pouch young less than 12 days old did not reject such grafts. Graft survival in such young extended to at least 80 days in most cases. When the question of induced tolerance to graft acceptance in five opossums with permanently surviving allografts was tested by regrafting with skin from the same donor, two of the animals rejected the second graft in a first-set fashion while the remainder maintained a viable second graft for over 90 days. All grafts from another donor were rejected within 20 days on these same animals. The initial graft never underwent any change regardless of what happened to subsequent grafts.

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