EFFECTS OF SURFACE ACTIVE AGENTS ON PELLET FORMATION IN SUBMERGED FERMENTATIONS OF STREPTOMYCES TENDAE.

Abstract
The effects of surface active agents on pellet formation in the filamentous bacterium Streptomyces tendae were investigated. Addition of pluronic F68 or Brij 58 at inoculation to the fermentation medium (up to 0·1% w/w) induced cellular aggregation. Below this concentration, the average pellet size increased with increasing surfactant concentration. Whereas, above this point inhibition of pellet formation was observed. Both surfactants caused aggregation of dispersed mycelia, when added after the fermentation.

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