The slotted crossover surface coil: A detector for in vivo NMR of skin

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Abstract
An elongated, narrow, slotted crossover surface coil provides surface localization capable of resolving in vivo 31 P NMR spectra from skin tissues. The shallow B1 field penetration achieves localization objectives while the probe length maintains signal-to-noise requirements. Dielectric and inductive losses are minimized via the crossover design (see T. L. Nagel et al., Magn. Reson. Med. 13, xxx (1990). In vivo spectra with millimeter depth resolution were acquired in 5 min at 2 T without pulse localization sequences. Preliminary 31P NMR spectra of normal and thermally injured rat skin were completed using a 25 × 3-mm slotted probe with a 3 × 2-cm surface region of excitation. Normal rat skin tissue PCr/Pi ratios ranged from 3.8 to 4.7 for 5-, 10-, and 30-γs pulse widths, while partial-and full-thickness scald injured tissues ranged from 0 to 2.8. Evaluation of a single minor partial thickness injury 1 to 5 h postburn shows evidence of a localized hypermetabolic response associated with hyperemia. Determination of bum depth and tissue viability appears feasible using: (1) PCr/Pi ratios and (2) observation of localized hypermetabolism. © 1990 Academic Press, Inc.

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