Natural regulatory T cells control the development of atherosclerosis in mice
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- 5 February 2006
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 12 (2) , 178-180
- https://doi.org/10.1038/nm1343
Abstract
Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke1,2. Here, we show that naturally arising CD4+CD25+ regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens3,4, are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.Keywords
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